Synthesis of HNMT, NNMT intermediates and PK
| Agency: | HEALTH AND HUMAN SERVICES, DEPARTMENT OF |
|---|---|
| State: | Maryland |
| Type of Government: | Federal |
| FSC Category: |
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| NAICS Category: |
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| Set Aside: | No Set aside used |
| Posted Date: | Aug 12, 2025 |
| Due Date: | Aug 19, 2025 |
| Solicitation No: | 75N95025Q00236 |
| Original Source: | Please Login to View Page |
| Contact information: | Please Login to View Page |
| Bid Documents: | Please Login to View Page |
Description
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- Contract Opportunity Type: Presolicitation (Original)
- Original Published Date: Aug 12, 2025 06:48 am EDT
- Original Response Date: Aug 19, 2025 12:00 pm EDT
- Inactive Policy: 15 days after response date
- Original Inactive Date: Sep 03, 2025
-
Initiative:
- None
- Original Set Aside: No Set aside used
- Product Service Code: B504 - SPECIAL STUDIES/ANALYSIS- CHEMICAL/BIOLOGICAL
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NAICS Code:
- 541380 - Testing Laboratories and Services
-
Place of Performance:
Rockville , MD 20850USA
NCATS is in need of custom synthesis and bioanalytical services in internal projects
focused on developing small molecule inhibitors of physiological small molecule
methyltransferases. NACTS is pursuing small molecules in two projects where
methyltransferases are implicated in disease. NCATS requires key intermediates that
will allow for the lab to scale up lead compounds or make analogs. NCATS also requires
exposure data in various tissues of interest to gauge compound concentrations to select
compounds for POC.
100g of N-(pyridin-3-yl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-e][1,4]diazepin-8-amine
100g of (tert-butyl (R)-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3- yl)piperidine-1-
carboxylate.
Mouse PK on at least 10 compounds with routes and tissues determined.
The final purity has to be >95% with optical purity >98%. Spectroscopic characterization
and analytical data will be required and verified.
- c/o 3WFN MSC 6012 301 N Stonestreet Ave
- Bethesda , MD 20892
- USA
- Andrew Varley
- andrew.varley@nih.gov
- Phone Number 3018275851
- Joshua T. Lazarus
- Josh.Lazarus@nih.gov
- Phone Number 3018276923
- Aug 12, 2025 06:48 am EDTPresolicitation (Original)
See Also
Follow PMX-281 IT Strategy, Software Modernization, and Digital Decision Intelligence Advisory Subscriptions Active
DEPT OF DEFENSE
Due by 11/11/2026
Formal Solicitation Details Solicitation Number RFP # 1200454 Bid Opening/ RFP Closing Date
Montgomery County
Due by 12/15/2026
ID: BPM058951 Title: CMAR FOR HISTORIC CONCORD MANOR Status: Open Due / Close
State Government of Maryland
Due by 11/17/2026
Follow PMX-281 IT Strategy, Software Modernization, and Digital Decision Intelligence Advisory Subscriptions Active
DEPT OF DEFENSE
Due by 11/11/2026