Smart Red Blood Cells (Smart-RBC)

Agency: DEPT OF DEFENSE
State: Federal
Type of Government: Federal
FSC Category:
  • A - Research and development
NAICS Category:
  • 541714 - Research and Development in Biotechnology (except Nanobiotechnology)
Posted Date: Oct 17, 2025
Due Date: Jan 14, 2026
Solicitation No: DARPA-PS-26-02
Original Source: Please Login to View Page
Contact information: Please Login to View Page
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Description

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Smart Red Blood Cells (Smart-RBC)
Active
Contract Opportunity
Notice ID
DARPA-PS-26-02
Related Notice
Department/Ind. Agency
DEPT OF DEFENSE
Sub-tier
DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
Office
DEF ADVANCED RESEARCH PROJECTS AGCY
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General Information
  • Contract Opportunity Type: Solicitation (Original)
  • Original Published Date: Oct 17, 2025 03:07 pm EDT
  • Original Date Offers Due: Jan 14, 2026 11:59 pm EST
  • Inactive Policy: Manual
  • Original Inactive Date: Feb 13, 2026
  • Initiative:
    • None
Classification
  • Original Set Aside:
  • Product Service Code: AC12 - NATIONAL DEFENSE R&D SERVICES; DEPARTMENT OF DEFENSE - MILITARY; APPLIED RESEARCH
  • NAICS Code:
    • 541714 - Research and Development in Biotechnology (except Nanobiotechnology)
  • Place of Performance:
Description
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals in support of the Smart Red Blood Cells program (Smart-RBC). The DARPA Smart-RBC program aims to engineer red blood cells to contain novel biological features that can safely, temporarily, and reliably alter human physiology. Specifically, the Smart-RBC program will revolutionize blood products by creating “smart red blood cells” (SRBCs). SRBCs will be engineered to contain additional biological circuits consisting of three layers: Sense extracellular biomarkers; Decide next steps; Act by creating effector molecules that can alter metabolism or physiology. The program will identify the art-of-the-possible to create SRBCs to enhance human performance and maximize survival via hemostasis products. This program does not include clinical trials or direct human testing.
Attachments/Links
Contact Information
Contracting Office Address
  • 675 NORTH RANDOLPH STREET
  • ARLINGTON , VA 222032114
  • USA
Primary Point of Contact
Secondary Point of Contact


History
  • Oct 17, 2025 03:07 pm EDTSolicitation (Original)
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