Request for Project Proposals: New Approach Methodologies (NAMs)

Agency: Department of the Army

Office: Army Contracting Command, Edgewood Contracting Division Location: Fort Detrick, MD, USA

Program Office: Capability Program Executive Office for CBRN Defense, Joint Project Management Office for CBRN Emerging Technologies

RPP Number: W911SR-26-9-NAMS Date Issued: June 1, 2026

Proposals Due: 1500 hours, June 12, 2026

1. Through this Request for Project Proposal (RPP), the Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense’s (CPE CBRND) Joint Product Lead for CBRN Emerging Technologies (JPL CBRN ET) seeks to advance New Approach Methodology (NAM) capabilities that reduce reliance on traditional animal models, de-risk Medical Countermeasure (MCM) development against CBRN threats and shorten MCM development timelines as described in the attached Statement of Objectives (SOO). In accordance with Section VIII.A.11 of announcement CBRND BAA 22-01, the Government is hereby requesting formal submission of preproposals to execute a formal agreement under 10 USC 4022, Other Transaction Authority (OTA) for the prototype project described below.

Upon receipt of a preproposal submitted in response to this RPP, the next steps are as follows:

• The Government will evaluate the preproposal.


• Discussions among the parties, whether verbally or in writing, will occur as appropriate.


• The Government may request a full proposal from the offeror.


• Additional discussions will occur as necessary.


• Award(s) may be made after evaluation and selection of a successful submission. (Note: Awards are dependent upon the availability of funds.)

2. This RPP is issued to request project proposals in compliance with USC 4022 and is being issued for planning purposes only. It is not to be construed as a commitment by the Government to award an agreement, nor will the Government pay for the information solicited.

3. The JPL CBRN ET is tasked with developing, manufacturing, and delivering safe and effective medical countermeasures capabilities against CBRN threats for deployed U.S. Forces. This effort intends to result in NAM capabilities that will reduce in vivo dependencies and enable faster fielding of MCMs to warfighters. Agreement under the authority of 10 USC 4022, with the expectation that quantities necessary for production, including fielding and testing new capabilities, may be non-competitively procured from awarded to the successful performer(s) of a prototype project in a follow-on production contract or other transaction agreement.

4. The Government will review/evaluate the submitted preproposals and if there is Government interest, the Agreements Officer may issue a request for full proposal (RFFP) in response to this RPP. The Government may award an agreement based on the submission or may require submission of additional details. The award of Prototype agreements shall be for the development of prototypes that are directly relevant to enhancing the mission effectiveness of personnel of the Department of Defense and the supporting platforms, systems, components, or materials proposed to be acquired or developed by the Department of Defense, or to improvement of platforms, systems, components, or materials in use by the Armed Forces. A prototype project can generally be described as a preliminary pilot, test, evaluation, demonstration, or agile development activity used to evaluate the technical or manufacturing feasibility or military utility of a particular technology, process, concept, end item, effect, or other discrete feature. Only a warranted Agreements Officer may obligate the U.S. Government to the expenditure of funds for awards under this Announcement.