PANDHA-25-P-0000_003354 DNA Aptamer-based Therapeutic Development

Agency: DEPT OF DEFENSE
State: Federal
Type of Government: Federal
FSC Category:
  • B - Special Studies and Analyses - Not R&D
NAICS Category:
  • 541714 - Research and Development in Biotechnology (except Nanobiotechnology)
Posted Date: Mar 25, 2025
Due Date: Apr 1, 2025
Solicitation No: PANDHA-25-P-0000_003354
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Description

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PANDHA-25-P-0000_003354 DNA Aptamer-based Therapeutic Development
Active
Contract Opportunity
Notice ID
PANDHA-25-P-0000_003354
Related Notice
Department/Ind. Agency
DEPT OF DEFENSE
Sub-tier
DEFENSE HEALTH AGENCY (DHA)
Office
ARMY MED RES ACQ ACTIVITY
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General Information
  • Contract Opportunity Type: Sources Sought (Original)
  • Original Published Date: Mar 25, 2025 08:03 am EDT
  • Original Response Date: Apr 01, 2025 10:00 am EDT
  • Inactive Policy: 15 days after response date
  • Original Inactive Date: Apr 16, 2025
  • Initiative:
    • None
Classification
  • Original Set Aside:
  • Product Service Code: B537 - SPECIAL STUDIES/ANALYSIS- MEDICAL/HEALTH
  • NAICS Code:
    • 541714 - Research and Development in Biotechnology (except Nanobiotechnology)
  • Place of Performance:
    BANGKOK , TH-10
    THA
Description

The objective of this contract is to conduct a two-year study on conjugated aptamers as antimicrobial agents to produce DNA aptamers conjugated with C1q- and Fc-domain proteins to create a biologic therapeutic with immunomodulatory antimicrobial activity against bacterial pathogens for wound infection. This shall include producing DNA aptamers that bind to the bacterial pathogen Pseudomonas aeruginosa; conjugating DNA aptamers to recombinant C1q protein and to recombinant IgG Fc domain protein to produce C1q- and Fc-conjugated DNA aptamers; validating that C1q- and Fc-conjugated DNA aptamers bind to Pseudomonas aeruginosa; and delivering C1q- and Fc-conjugated DNA aptamers to WRAIR, AFRIMS for testing, located in Bangkok, Thailand.


Attachments/Links
Contact Information
Contracting Office Address
  • 808 SCHREIDER ST
  • FORT DETRICK , MD 21702
  • USA
Primary Point of Contact
Secondary Point of Contact
History
  • Mar 25, 2025 08:03 am EDTSources Sought (Original)
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