Olink Explorer >5400

Requirements:

2.0 BACKGROUND

Our lab studies the role of inflammation/innate resistance and commensal microbiota in carcinogenesis, cancer progression and therapy of cancer.

The following product features/characteristics are required for this requirement:

Protein Coverage - Measures ~5,400+ human proteins simultaneously in a single workflow.

Technology - Uses Proximity Extension Assay (PEA) with dual antibody recognition coupled to DNA barcoding and next-generation sequencing (NGS) readout.

Sample input – requires only 2 ul of plasma, serum, and other sample types

Specificity - Reported 99.5% specificity with negligible cross-reactivity due to dual-recognition antibody design.

Dynamic Range - Approximately 10 orders of magnitude (fg/mL to mg/mL), enabling detection of both low- and high-abundance proteins.

Key strengths

• Very broad proteome coverage while maintaining antibody-based specificity.

• Excellent sensitivity for low-abundance circulating proteins (especially cytokines and signaling proteins).

• Extremely low sample-volume requirement.

• Highly standardized platform, making it attractive for epidemiology and multi-omics studies.