Fully integrated dual YAG/SLT ophthalmic laser system with associated accessories

Statement of Need and Purpose:

This acquisition is necessary to provide supplies and reagents to the Neurodegenerative

Diseases Research Section for neurodegenerative disease research for proteomic analyses.

2. Background Information and Objective:

Our project is focused on advancing our understanding of neurodegenerative diseases,

particularly parkinsonism syndromes, through detailed analyses of human samples using

state-of-the-art Olink Explore assays. By leveraging these assays, we will perform highresolution

proteomics to map protein expression profiles across samples obtained from

patients, thereby illuminating the complex molecular landscape of neurodegeneration.

3. Generic Name of Product:

Human Olink Explore HT Assay Kit

4. Purchase Description:

Item Description Cat no Quantity Total Cost

Olink Explore HT Reagent Kit 98100 3 @ $68,800 ea $206,400.00

Shipping and Handling 0001-Shipping 1 @ $461.31 $461.31

Order Total $206,861.31

5. Salient characteristics.

All deliverables required under this contract shall be packaged, marked, and shipped in

accordance with Government specifications. At a minimum, all deliverables shall be marked

with the contract number and the Contractor's name. The Contractor shall guarantee that all

required materials shall be delivered in an immediately usable and acceptable condition.

The vendor must be able to provide these specifications:

• Must use an antibody-based approach to map protein abundance levels within samples.

• Must provide the abundance levels for thousands of proteins within the samples.

• Must be able to provide data that can be mapped to human biological pathways and

processes that are potentially targetable by therapeutics.

6. Quantity:

Item Description Cat no Quantity Total Cost

Olink Explore HT Reagent Kit 98100 3 @ $68,800 ea $206,400.00

Shipping and Handling 0001-Shipping 1 @ $461.31 $461.31

Order Total $206,861.31