|Agency:||HEALTH AND HUMAN SERVICES, DEPARTMENT OF|
|Type of Government:||Federal|
|Posted Date:||Jul 2, 2020|
|Due Date:||Jul 17, 2020|
|Bid Source:||Please Login to View Page|
|Contact information:||Please Login to View Page|
|Bid Documents:||Please Login to View Page|
Laboratory mice are common experimental animals in biological, medical, pharmacological and psychological researches primarily because they are easy to maintain and reproduce quickly Dissection of brain tissue is an important step in sample preparation for (subcellular) proteomics studies. Some Labs (vendors) can perform brain removal and separate dissection of multiple brain regions from a single brain and follow a step-by-step protocol. This concerns dissection from fresh or frozen tissue of cerebellum, hippocampus, prefrontal cortex, and striatum for protein immunoblot and/or neuronal culture, providing technical reference information for minimizing the number of animals used in projects, and refining methods and procedures to quick brain dissection, embedding and staining. NeuroScience Associates is one of the rare companies that can perform all stages in one Lab over a period of time with consistent and accurate results.
The Lab needs to investigate the effect of overexpression of carboxypeptidase E-neurotrophic factor 1 in the hippocampus on prevention or treatment of neurodegeneration and cognitive dysfunction in the Alzheimer's Disease mouse model”, and proposes to inject AAV-CPE into mouse brain at 2 month of age and evaluate the pathophysiological and behavioral changes at 6-7 months of age, to study whether CPE has prevented the development of AD. Also, they will inject AAV-CPE into mouse brain at 4 months of age when there is intracellular accumulation of Aβ, and pathophysiological and behavioral changes evaluated at 6 -7 months of age, to determine whether CPE has any therapeutic effect.
This proposed procurement is for a service for which the government intends to solicit and negotiate on a sole source basis to NeuroScience Associates located in Knoxville, TN. 37934. In order to comply with the requirements in this Special Notice, the responses should be based on our interpretation of the general requirements provided below.
Note 22. The proposed contract action is for a continuation of previous services for which the Government intends to solicit and negotiate with only one source under the authority of FAR 6.302. Interested persons may identify their interest and capability to respond to the requirement or submit quotations. This notice of intent is not a request for competitive quotes. However, all quotes received within the time and date of publication of this "Special Note 22" will be considered by the Government. A determination by the Government not to compete with this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive procurement.
HOW TO RESPOND: In order to compete for this project, interested parties must be registered in the Central Contracting Registration and submit a price quotation by 11:00 am, ET, July 17th 2020. Offerors may either submit one copy of the quote to MOE FILALI by mail or preferably via email. Electronic transmissions to Moe.Filali@nih.gov are preferable but must be timely. It is the responsibility of the Offeror to ensure the proposal is received by the date and time shown above.
The following Federal Acquisition Regulations clauses are incorporated by reference: FAR 52.212-3, Offeror Representations and Certifications-Commercial Items (Mar 2005), 52.212-4 (Sept 2005), 52.212-5, Contract Terms and Conditions Required to Implement Statutes of Executive Orders-Commercial Items (Aug 2006). (6)(i) 52.222-26, Equal Opportunity (Apr 2002) (E.O. 11246). (18) 52.222-35, Equal Opportunity for Special Disabled Veterans, Veterans of the Vietnam Era, and Other Eligible Veterans (Dec 2001) (38 U.S.C. 4212). (19) 52.222-36, Affirmative Action for Workers with Disabilities (Jun 1998) (29 U.S.C. 793). (20) 52.222-37, Employment Reports on Special Disabled Veterans, Veterans of the Vietnam Era, and Other Eligible Veterans (Dec 2001) (38 U.S.C. 4212). (31) 52.232-33, Payment by Electronic Funds Transfer-Central Contractor Registration (Oct 2003) (31 U.S.C. 3332).
Primary Point of Contact:
MOE FILALI Contracting Office Address:
NIH/NICHD Office of Acquisitions
6710B Rockledge Drive, Room 1145D
Bethesda, MD 20817
(w) 301.827 7737
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