| A -- Bacterial Population Genetics in a Forensics Context (BPGFC) |
| Program Summary |
 |
| Title: |
A -- Bacterial Population Genetics in a Forensics Context (BPGFC) |
| GovCB Opps ID : |
ADP12054271310001117 |
| Document Type: |
Presolicitation Notice |
| FSC Code: |
A - Research and development
|
| Solicitation No.: |
BAA08-04 |
| Source: |
http://www2.fbo.gov/spg/DHS/OCPO/DHS%2DOCPO/BAA08%2D04/SynopsisP.html |
Posted Date:
|
Mar 12, 2008 |
| Last Update: |
Jul 09, 2008 |
| Due Date: |
May 30, 2008 |
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| Description |
|
General Information
| Document Type: |
Presolicitation Notice |
| Solicitation Number: |
BAA08-04 |
| Posted Date: |
Mar 12, 2008 |
| Original Response Date: |
May 30, 2008 |
| Current Response Date: |
May 30, 2008 |
| Original Archive Date: |
Jun 14, 2008 |
| Current Archive Date: |
Jun 14, 2008 |
| Classification Code: |
A -- Research & Development |
| Naics Code: |
541712 -- Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology) |
Contracting Office Address
Department of Homeland Security, Office of the Chief Procurement Officer, Office of Procurement Operations, Office of the Chief Procurement Officer, Washington, DC, 20528, UNITED STATES
Description
The goal of this DHS Science & Technology research program is to develop algorithms and/or analytical tools that will assist investigators of bioterrorism events by providing precision and statistical power to inferences concerning the degree of relatedness among organisms or samples used in a bioterrorist event. The focus of this effort will be on research in the areas microbial ecology, population dynamics, host-pathogen interaction. genetic stability, statistical inference, and match criteria for the following select agents: Bacillus anthracis, Yersinia pestis, Clostridium botulinum, Francisella tularensis, Brucella sp., Escherichia coli O157:H7, Burkholderia mallei, Burkholderia pseudomallei. The objectives include:
1. Improving our understanding of the population genetics of these pathogens to include research on genome stability, host preferences and interactions, genetic mobility of virulence factors, polymorphic sites, mutational hot spots, geographical distribution, microbial ecology, pathogen lifecycles, natural reservoirs, effects of host - pathogen interaction, etc.
2. Improving methods for determining rates of mutation and recombination of the pathogen genomes and the identification of adaptive mutations that can have forensic utility
3. Establishing match criteria for discriminating "difference" or "sameness" in sample comparisons. Define the parameters for inclusion or exclusion in the context of a known sample and questioned sample. This must be backed by statistical parameters for acceptance or rejection of the null hypothesis
4. Developing efficient, economical, and statistically rigorous sampling strategies to acquire spatially referenced genetic information on reservoirs of these pathogens
5. Developing bioinformatics-based analytical tools for supporting hypotheses testing regarding pathogen origin that go beyond current phylogeny-based inferential methods and can meet forensic (legal) admissibility requirements of relevance and reliability.
Multiple awards are anticipated under this BAA. This BAA has a registration process -- please see Section IV of the BAA. Prospective Offerors must ensure that they allow sufficient time to complete the registration and submission process.
Point of Contact
Timothy Davis, Contracting Officer, Phone 202-254-5676, Fax 202-254-6167, Email timothy.davis@hq.dhs.gov
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